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Welcome to the Carreira Research Group

Professor Carreira's research program focuses on the asymmetric synthesis of biologically active, stereochemically complex, natural products. Target molecules are selected which pose unique challenges in asymmetric bond construction. A complex multistep synthesis endeavor provides a goal-oriented setting within which to engage in reaction innovation and design. Drawing from the areas of organometallic chemistry, coordination chemistry, and molecular recognition, Carreira's group is developing catalytic and stoichiometric reagents for asymmetric stereocontrol.

Recent Publications

Check out these recent publications from the Carreira lab:

J. Ruchti, E. M. Carreira, Org. Lett. 2016, 18, 2174-2176.
Rh-Catalyzed Stereospecific Synthesis of Allenes from Propargylic Benzoates and Arylboronic Acids.

S. Krautwald, C. Nilewski, M. Mori, K. Shiomi, S. Omura, E. M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 4049–4053.
Bioisosteric Exchange of Csp3-Chloro and Methyl Substituents: Snythesis and Initial Biological Studies of Atpenin A5 Analogues.

S. Fischer, N. Huwyler, S. Wolfrum, E. M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 2555–2558.
Synthesis and Biological Evaluation of Bromo- and Fluorodanicalipin A.

A. Joliton, J.-M. Plancher, E. M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 2113–2117.
Formation of α-SF5-Enolate Enables Preparation of 3-SF5-Quinolin-2-ones, 3-SF5-Quinolines, and 3-SF5-Pyridin-2-ones: Evaluation of their Physiochemical Properties.  

S. A. Ruider, E. M. Carreira, Org. Lett. 2016, 18, 220.
A Unified Strategy to Plakortin Pentalenes: Total Syntheses of (±)-Gracilioethers E and F.

A. M. Bailey, S. Wolfrum, E. M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 639.
Biological Investigations of (+)-Danicalipin A Enabled Through Synthesis.

C. Nilewski, C. Le Chapelain, Susanne Wolfrum, E. M. Carreira, Org. Lett. 2015, 17, 5602.
Synthesis and Biological Evaluation of Chlorinated Analogs of Leukotoxin Diol.

T. Sandmeier, S. Krautwald, H. F. Zipfel, E. M. Carreira, Angew. Chem. Int. Ed. 2015, 54, 14363.
Stereodivergent Dual Catalyticα-Allylation of Protected α-Amino- and α-Hydroxyacetaldehydes.

J. Egger, S. Fischer, P. Bretscher, S. Freigang, M. Kopf, E. M. Carreira, Org. Lett. 2015, 17, 4340.
Total Synthesis of Prostaglandin 15d-PGJ2 and Investigations of its Effect on the Secretion of IL-6 and IL-12.

C. Ebner, E. M. Carreira, Angew. Chem. Int. Ed. 2015, 54, 11227.
Pentafulvene for the Synthesis of Complex Natural Products: Total Synthesis of (±)-Pallambins A and B.

 
 
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24.05.2016
© 2016 Eidgenössische Technische Hochschule Zürich