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Welcome to the Carreira Research Group

Professor Carreira's research program focuses on the asymmetric synthesis of biologically active, stereochemically complex, natural products. Target molecules are selected which pose unique challenges in asymmetric bond construction. A complex multistep synthesis endeavor provides a goal-oriented setting within which to engage in reaction innovation and design. Drawing from the areas of organometallic chemistry, coordination chemistry, and molecular recognition, Carreira's group is developing catalytic and stoichiometric reagents for asymmetric stereocontrol.

Carreira Group Lisbon 2016  
Carreira Group Lisbon 2016

Recent Publications

Check out these recent publications from the Carreira lab:

T. Sandmeier, S. Krautwald, E.M. Carreira, Angew. Chem. Int. Ed. 2017, Accepted Article. Stereoselective Synthesis of Piperidines via Iridium-Catalyzed Cyclocondensation.

H. Wolleb, E.M. Carreira, Angew. Chem. Int. Ed. 2017, Accepted ArticleTotal Synthesis of (+)-Dendrowardol C.  

J.Y. Hamilton, S.L. Rössler, E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 8082–8085. Enantio- and Diastereoselective Spiroketalization Catalyzed by Chiral Iridium Complex.

M.A. Schafroth, S.M. Rummelt, D. Sarlah, E.M. Carreira, Org. Lett. 2017, 19, 3235–3238. Enantioselective Iridium-Catalyzed Allylic Cyclizations.

M. Hönig, P. Sondermann, N. Turner, E.M. Carreira, Angew. Chem. Int. Ed. 2017, Accepted Article. Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis.

C. Ebner and E.M. Carreira, Chem. Rev. 2017, ASAP. Cyclopropanation Strategies in Recent Total Syntheses.

G.P. Möller, S. Müller, B.T. Wolfstädter, S. Wolfrum, D. Schepmann, B. Wünsch, E.M. Carreira, Org. Lett. 2017, 19, 2510–2513. Oxetanyl Amino Acids for Peptidomimetics.

S. Krautwald and E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 5627–5639. Stereodivergence in Asymmetric Catalysis.

S.L. Rössler, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 3603–3606. Study of Intermediates in Iridium–(Phosphoramidite,Olefin)-Catalyzed Enantioselective Allylic Substitution.

R. Vorberg, E.M. Carreira, K. Müller, ChemMedChem 2017, 12, 431–437. Aqueous Instability of δ-Fluorobutylpiperidines

Q.A. Huchet, N. Trapp, B. Kuhn, B. Wagner, H. Fischer, N.A. Kratochwil, E.M. Carreira, K. Müller, J. Fluorine Chem. 2017, in press. Partially fluorinated alkoxy groups − Conformational adaptors to changing environments.

R. Vorberg, E.M. Carreira, K. Müller, Chem. Eur. J. 2017, 23, 3126–3138. Bicyclo[3.2.0]heptane as a Core Structure for Conformational Locking of 1,3-Bis-Pharmacophores, Exemplified by GABA.

M.A. Schafroth, E.M. Carreira. Synthesis of Phytocannabinoids. In Phytocannabinoids; A. D. Kinghorn, H. Falk, S. Gibbons, J. Kobayashi, Eds.; Progress in the Synthesis of Organic Natural Products Series 103; Springer: Switzerland, 2017; pp 37–59. "Synthesis of Phytocannabinoids".

Y. Sempere Molina, J. Ruchti, E.M. Carreira, Org. Lett. 2017, 19, 743–745Enantioselective Addition of Alkynes to α,α-Dichlorinated Aldehydes.  

Q.A. Huchet, W. B. Schweizer, B. Kuhn, E.M. Carreira, K. Müller, Chem. Eur. J.  2016, 22, 16920–16928. Structural and Conformational Aspects of Equatorial and Axial Trifluoromethyl, Difluoromethyl, and Monofluoromethyl Groups.

R. Vorberg, N. Trapp, D. Zimmerli, B. Wagner, H. Fischer, N.A. Kratochwil, M. Kansy, E.M. Carreira, K. Müller, ChemMedChem 2016, 11, 2216–2239. Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties.

J. Ruchti, E.M. Carreira, Org. Lett. 2016, 18, 2174–2176.
Rh-Catalyzed Stereospecific Synthesis of Allenes from Propargylic Benzoates and Arylboronic Acids.

S. Krautwald, C. Nilewski, M. Mori, K. Shiomi, S. Omura, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 4049–4053.
Bioisosteric Exchange of Csp3-Chloro and Methyl Substituents: Snythesis and Initial Biological Studies of Atpenin A5 Analogues.

S. Fischer, N. Huwyler, S. Wolfrum, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 2555–2558.
Synthesis and Biological Evaluation of Bromo- and Fluorodanicalipin A.

A. Joliton, J.-M. Plancher, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 2113–2117.
Formation of α-SF5-Enolate Enables Preparation of 3-SF5-Quinolin-2-ones, 3-SF5-Quinolines, and 3-SF5-Pyridin-2-ones: Evaluation of their Physiochemical Properties.  

S.A. Ruider, E.M. Carreira, Org. Lett. 2016, 18, 220.
A Unified Strategy to Plakortin Pentalenes: Total Syntheses of (±)-Gracilioethers E and F.

A.M. Bailey, S. Wolfrum, E.M. Carreira, Angew. Chem. Int. Ed. 2016, 55, 639.
Biological Investigations of (+)-Danicalipin A Enabled Through Synthesis.

 
 
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